Lisa Maria Potthoff grew up in Munich as the child of a doctor and a psychologist and completed her acting training there at Schauspiel München from 1997 to 1999. Even before and during her training, she had her first roles in various television series such as Polizeiruf 110 and SOKO 5113 starting in 1995. She had leading roles in the television films Bittere Unschuld, Holstein Lovers, Ein Weihnachtsmärchen, Sommerwind, Blond: Eva Blond!, Der Tod ist kein Beweis, and alongside Herbert Knaups in Die Tochter des Kommissars. In recent years, Potthoff has also played leading roles in feature films, including "Braut Sophie" in the black comedy Die Bluthochzeit, "Nadja" in Soloalbum, "Susanne," manager of a gay soccer team, in Männer wie wir, and "Eleonore Schikaneder" in Marcus H. Rosenmüller's "Sommer der Gaukler". Since 2014 she has played police officer Sarah Kohr in the crime series of the same name.